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Remote meta ‐C–H Cyanation of Arenes Enabled by a Pyrimidine‐Based Auxiliary
Author(s) -
Bag Sukdev,
Jayarajan Ramasamy,
Dutta Uttam,
Chowdhury Rajdip,
Mondal Rahul,
Maiti Debabrata
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201706360
Subject(s) - cyanation , pyrimidine , chemistry , cyanide , scope (computer science) , combinatorial chemistry , ether , organic chemistry , catalysis , stereochemistry , computer science , programming language
An easily removable pyrimidine‐based auxiliary has been employed for the remote meta ‐C−H cyanation of arenes. The scope of this Pd‐catalyzed cyanation reaction using copper(I) cyanide as the cyanating agent was demonstrated with benzylsilanes, benzylsulfonates, benzylphophonates, phenethylsulfonates, and phenethyl ether derivatives. The method was utilized for the synthesis of pharmaceutically valuable precursors.