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Selective Palladium(II)‐Catalyzed Carbonylation of Methylene β‐C−H Bonds in Aliphatic Amines
Author(s) -
CabreraPardo Jaime R.,
Trowbridge Aaron,
Nappi Manuel,
Ozaki Kyohei,
Gaunt Matthew J.
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201706303
Subject(s) - carbonylation , xantphos , palladium , chemistry , catalysis , methylene , organic chemistry , allene , medicinal chemistry , carbon monoxide
Palladium(II)‐catalyzed C−H carbonylation reactions of methylene C−H bonds in secondary aliphatic amines lead to the formation of trans ‐disubstituted β‐lactams in excellent yields and selectivities. The generality of the C−H carbonylation process is aided by the action of xantphos‐based ligands and is important in securing good yields for the β‐lactam products.