Nucleophilic Amination of Methoxy Arenes Promoted by a Sodium Hydride/Iodide Composite | Zendy

Kaga Atsushi | Zendy; Hayashi Hirohito | Zendy; Hakamata Hiroyuki | Zendy; Oi Miku | Zendy; Uchiyama Masanobu | Zendy; Takita Ryo | Zendy; Chiba Shunsuke | Zendy

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Nucleophilic Amination of Methoxy Arenes Promoted by a Sodium Hydride/Iodide Composite

Author(s) -

Kaga Atsushi,

Hayashi Hirohito,

Hakamata Hiroyuki,

Oi Miku,

Uchiyama Masanobu,

Takita Ryo,

Chiba Shunsuke

Publication year - 2017

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201705916

Subject(s) - amination , sodium hydride , iodide , nucleophile , composite number , hydride , chemistry , sodium iodide , sodium , medicinal chemistry , organic chemistry , catalysis , materials science , composite material , hydrogen

A method for the nucleophilic amination of methoxy arenes was established by using sodium hydride (NaH) in the presence of lithium iodide (LiI). This method offers an efficient route to benzannulated nitrogen heterocycles. Mechanistic studies showed that the reaction proceeds through an unusual concerted nucleophilic aromatic substitution.

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