Palladium‐Catalyzed Enantioselective Narasaka–Heck Reaction/Direct C−H Alkylation of Arenes: Iminoarylation of Alkenes | Zendy

Bao Xu | Zendy; Wang Qian | Zendy; Zhu Jieping | Zendy

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Palladium‐Catalyzed Enantioselective Narasaka–Heck Reaction/Direct C−H Alkylation of Arenes: Iminoarylation of Alkenes

Author(s) -

Bao Xu,

Wang Qian,

Zhu Jieping

Publication year - 2017

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201705641

Subject(s) - enantioselective synthesis , palladium , chemistry , intramolecular force , phosphine , heck reaction , alkylation , catalysis , denticity , medicinal chemistry , ligand (biochemistry) , organic chemistry , combinatorial chemistry , crystal structure , biochemistry , receptor

A palladium‐catalyzed reaction of γ,δ‐unsaturated oxime esters with oxadiazoles afforded dihydropyrroles in good to excellent yields through an intramolecular iminopalladation/intermolecular direct heteroarene C−H alkylation cascade. This unprecedented iminoarylation of alkenes was subsequently realized in an enantioselective manner in the presence of a chiral bidentate phosphine ligand (Synphos).

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