Premium
Palladium‐Catalyzed Enantioselective Narasaka–Heck Reaction/Direct C−H Alkylation of Arenes: Iminoarylation of Alkenes
Author(s) -
Bao Xu,
Wang Qian,
Zhu Jieping
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201705641
Subject(s) - enantioselective synthesis , palladium , chemistry , intramolecular force , phosphine , heck reaction , alkylation , catalysis , denticity , medicinal chemistry , ligand (biochemistry) , organic chemistry , combinatorial chemistry , crystal structure , biochemistry , receptor
A palladium‐catalyzed reaction of γ,δ‐unsaturated oxime esters with oxadiazoles afforded dihydropyrroles in good to excellent yields through an intramolecular iminopalladation/intermolecular direct heteroarene C−H alkylation cascade. This unprecedented iminoarylation of alkenes was subsequently realized in an enantioselective manner in the presence of a chiral bidentate phosphine ligand (Synphos).