Premium
Gold‐Triggered Uncaging Chemistry in Living Systems
Author(s) -
PérezLópez Ana M.,
RubioRuiz Belén,
Sebastián Víctor,
Hamilton Lloyd,
Adam Catherine,
Bray Thomas L.,
Irusta Silvia,
Brennan Paul M.,
LloydJones Guy C.,
Sieger Dirk,
Santamaría Jesús,
UncitiBroceta Asier
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201705609
Subject(s) - bioorthogonal chemistry , chemistry , nanotechnology , combinatorial chemistry , reagent , catalysis , small molecule , biochemistry , click chemistry , materials science , organic chemistry
Recent advances in bioorthogonal catalysis are increasing the capacity of researchers to manipulate the fate of molecules in complex biological systems. A bioorthogonal uncaging strategy is presented, which is triggered by heterogeneous gold catalysis and facilitates the activation of a structurally diverse range of therapeutics in cancer cell culture. Furthermore, this solid‐supported catalytic system enabled locally controlled release of a fluorescent dye into the brain of a zebrafish for the first time, offering a novel way to modulate the activity of bioorthogonal reagents in the most fragile and complex organs.