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NOAH: NMR Supersequences for Small Molecule Analysis and Structure Elucidation
Author(s) -
Kupče Ēriks,
Claridge Tim D. W.
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201705506
Subject(s) - heteronuclear single quantum coherence spectroscopy , two dimensional nuclear magnetic resonance spectroscopy , chemistry , nuclear magnetic resonance spectroscopy , molecule , fluorine 19 nmr , natural product , pulse sequence , transverse relaxation optimized spectroscopy , proton nmr , carbon 13 nmr , stereochemistry , nuclear magnetic resonance , organic chemistry , physics
Nested NMR experiments combining up to five conventional NMR pulse sequences into one supersequence are introduced. The core 2D NMR techniques routinely employed in small molecule NMR spectroscopy, such as HSQC, HMQC, HMBC, COSY, NOESY, TOCSY, and similar, can be recorded in a single measurement. In this way the data collection time may be dramatically reduced and sample throughput increased for basic NMR applications, such as structure elucidation and verification in synthetic, medicinal, and natural product chemistry.