Anti‐Markovnikov Hydrofunctionalization of Alkenes: Use of a Benzyl Group as a Traceless Redox‐Active Hydrogen Donor | Zendy

Lonca Geoffroy Hervé | Zendy; Ong Derek Yiren | Zendy; Tran Thi Mai Huong | Zendy; Tejo Ciputra | Zendy; Chiba Shunsuke | Zendy; Gagosz Fabien | Zendy

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Anti‐Markovnikov Hydrofunctionalization of Alkenes: Use of a Benzyl Group as a Traceless Redox‐Active Hydrogen Donor

Author(s) -

Lonca Geoffroy Hervé,

Ong Derek Yiren,

Tran Thi Mai Huong,

Tejo Ciputra,

Chiba Shunsuke,

Gagosz Fabien

Publication year - 2017

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201705368

Subject(s) - markovnikov's rule , chemistry , redox , combinatorial chemistry , hydrogen , organic chemistry , catalysis , regioselectivity

A protocol for the anti‐Markovnikov hydrofunctionalization of alkenes has been developed by the use of a benzyl group as a traceless redox‐active hydrogen donor. Under copper catalysis and in the presence of CF 3 ‐ or N 3 ‐containing hypervalent iodine reagents, a series of homoallylic alcohol derivatives were hydrofunctionalized regioselectivity. A similar principle was also applied to the hydrofunctionalization of alkenols.

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