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Anti‐Markovnikov Hydrofunctionalization of Alkenes: Use of a Benzyl Group as a Traceless Redox‐Active Hydrogen Donor
Author(s) -
Lonca Geoffroy Hervé,
Ong Derek Yiren,
Tran Thi Mai Huong,
Tejo Ciputra,
Chiba Shunsuke,
Gagosz Fabien
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201705368
Subject(s) - markovnikov's rule , chemistry , redox , combinatorial chemistry , hydrogen , organic chemistry , catalysis , regioselectivity
A protocol for the anti‐Markovnikov hydrofunctionalization of alkenes has been developed by the use of a benzyl group as a traceless redox‐active hydrogen donor. Under copper catalysis and in the presence of CF 3 ‐ or N 3 ‐containing hypervalent iodine reagents, a series of homoallylic alcohol derivatives were hydrofunctionalized regioselectivity. A similar principle was also applied to the hydrofunctionalization of alkenols.