Inside Cover: Total Synthesis of Aplydactone by a Conformationally Controlled C−H Functionalization (Angew. Chem. Int. Ed. 28/2017) | Zendy

Liu Chenguang | Zendy; Chen Renzhi | Zendy; Shen Yang | Zendy; Liang Zhanhao | Zendy; Hua Yuhui | Zendy; Zhang Yandong | Zendy

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Inside Cover: Total Synthesis of Aplydactone by a Conformationally Controlled C−H Functionalization (Angew. Chem. Int. Ed. 28/2017)

Author(s) -

Liu Chenguang,

Chen Renzhi,

Shen Yang,

Liang Zhanhao,

Hua Yuhui,

Zhang Yandong

Publication year - 2017

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Reports

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201705178

Subject(s) - surface modification , int , cover (algebra) , total synthesis , chemistry , stereochemistry , combinatorial chemistry , computer science , engineering , mechanical engineering , operating system

The brominated sesquiterpene aplydactone has been synthesized by a C−H functionalization strategy. In their Communication on page 8187 ff., Y. Zhang and co‐workers demonstrate that conformation fine‐tuning supported by calculations is key to the success of the C−H insertion. The late‐stage C−H functionalization and HAT hydrogenation enabled a concise protecting‐group‐free approach to aplydactone.

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