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Inside Cover: Total Synthesis of Aplydactone by a Conformationally Controlled C−H Functionalization (Angew. Chem. Int. Ed. 28/2017)
Author(s) -
Liu Chenguang,
Chen Renzhi,
Shen Yang,
Liang Zhanhao,
Hua Yuhui,
Zhang Yandong
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201705178
Subject(s) - surface modification , int , cover (algebra) , total synthesis , chemistry , stereochemistry , combinatorial chemistry , computer science , engineering , mechanical engineering , operating system
The brominated sesquiterpene aplydactone has been synthesized by a C−H functionalization strategy. In their Communication on page 8187 ff., Y. Zhang and co‐workers demonstrate that conformation fine‐tuning supported by calculations is key to the success of the C−H insertion. The late‐stage C−H functionalization and HAT hydrogenation enabled a concise protecting‐group‐free approach to aplydactone.