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Highly Selective Artificial Potassium Ion Channels Constructed from Pore‐Containing Helical Oligomers
Author(s) -
Lang Chao,
Deng Xiaoli,
Yang Feihu,
Yang Bing,
Wang Wei,
Qi Shuaiwei,
Zhang Xin,
Zhang Chenyang,
Dong Zeyuan,
Liu Junqiu
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201705048
Subject(s) - oligomer , transmembrane channels , ion channel , ion , kcsa potassium channel , chemistry , potassium channel , stacking , membrane , potassium , ion transporter , transmembrane protein , selectivity , crystallography , biophysics , voltage gated ion channel , polymer chemistry , biochemistry , organic chemistry , catalysis , biology , receptor
Potassium ion channels specifically transport K + ions over Na + ions across a cell membrane. A queue of four binding sites in the K + channel pore plays significant roles during highly selective conduction. A kind of aromatic helical oligomer was synthesized that can selectively bind K + over Na + . By aromatic stacking of helical oligomers, a type of artificial K + channels with contiguous K + binding sites was constructed. Such artificial channels exhibited exceptionally high K + /Na + selectivity ratios during transmembrane ion conduction.