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Co‐assembly of Patchy Polymeric Micelles and Protein Molecules
Author(s) -
Fan Weijing,
Liu Li,
Zhao Hanying
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201704955
Subject(s) - micelle , biomolecule , copolymer , molecule , bovine serum albumin , polymer , nanoparticle , self assembly , vesicle , template , chemistry , nanotechnology , chemical engineering , materials science , organic chemistry , chromatography , membrane , aqueous solution , biochemistry , engineering
The development in the synthesis and self‐assembly of patchy nanoparticles has resulted in the creation of complex hierarchical structures. Co‐assembly of polymeric nanoparticles and protein molecules combines the advantages of polymeric materials and biomolecules, and will produce new functional materials. Co‐assembly of positively charged patchy micelles and negatively charged bovine serum albumin (BSA) molecules is investigated. The patchy micelles, which were synthesized using block copolymer brushes as templates, leads to co‐assembly with protein molecules into vesicular structures. The average size of the assembled structures can be controlled by the molar ratio of BSA to patchy micelles. The assembled structures are dissociated in the presence of trypsin. The protein–polymer hybrid vesicles could find potential applications in medicine.