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Silver‐Catalyzed Oxidative C(sp 3 )−P Bond Formation through C−C and P−H Bond Cleavage
Author(s) -
Li Lili,
Huang Wenbin,
Chen Lijin,
Dong Jiaxing,
Ma Xuebing,
Peng Yungui
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201704910
Subject(s) - bond cleavage , regioselectivity , catalysis , chemistry , cleavage (geology) , oxidative phosphorylation , oxidative coupling of methane , functional group , oxidative cleavage , selectivity , medicinal chemistry , stereochemistry , organic chemistry , materials science , biochemistry , polymer , fracture (geology) , composite material
The silver‐catalyzed oxidative C(sp 3 )−H/P−H cross‐coupling of 1,3‐dicarbonyl compounds with H‐phosphonates, followed by a chemo‐ and regioselective C(sp 3 )−C(CO) bond‐cleavage step, provided heavily functionalized β‐ketophosphonates. This novel method based on a readily available reaction system exhibits wide scope, high functional‐group tolerance, and exclusive selectivity.