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Ceria–Zirconia Nanoparticles as an Enhanced Multi‐Antioxidant for Sepsis Treatment
Author(s) -
Soh Min,
Kang DongWan,
Jeong HanGil,
Kim Dokyoon,
Kim Do Yeon,
Yang Wookjin,
Song Changyeong,
Baik Seungmin,
Choi InYoung,
Ki SeulKi,
Kwon Hyek Jin,
Kim Taeho,
Kim Chi Kyung,
Lee SeungHoon,
Hyeon Taeghwan
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201704904
Subject(s) - reactive oxygen species , nanomedicine , nanoparticle , cubic zirconia , antioxidant , sepsis , materials science , inflammation , nanotechnology , chemistry , nuclear chemistry , medicine , biochemistry , metallurgy , immunology , ceramic
The two oxidation states of ceria nanoparticles, Ce 3+ and Ce 4+ , play a pivotal role in scavenging reactive oxygen species (ROS). In particular, Ce 3+ is largely responsible for removing O 2 − and . OH that are associated with inflammatory response and cell death. The synthesis is reported of 2 nm ceria–zirconia nanoparticles (CZ NPs) that possess a higher Ce 3+ /Ce 4+ ratio and faster conversion from Ce 4+ to Ce 3+ than those exhibited by ceria nanoparticles. The obtained Ce 0.7 Zr 0.3 O 2 (7CZ) NPs greatly improve ROS scavenging performance, thus regulating inflammatory cells in a very low dose. Moreover, 7CZ NPs are demonstrated to be effective in reducing mortality and systemic inflammation in two representative sepsis models. These findings suggest that 7CZ NPs have the potential as a therapeutic nanomedicine for treating ROS‐related inflammatory diseases.