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Nanoscale Metal–Organic Layers for Deeply Penetrating X‐ray‐Induced Photodynamic Therapy
Author(s) -
Lan Guangxu,
Ni Kaiyuan,
Xu Ruoyu,
Lu Kuangda,
Lin Zekai,
Chan Christina,
Lin Wenbin
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201704828
Subject(s) - sbus , nanoscopic scale , chemistry , metal , photodynamic therapy , energy transfer , photochemistry , bipyridine , phosphorescence , metal organic framework , reactive oxygen species , materials science , crystallography , nanotechnology , fluorescence , organic chemistry , physics , optics , biochemistry , adsorption , molecular physics , crystal structure
Abstract We report the rational design of metal–organic layers (MOLs) that are built from [Hf 6 O 4 (OH) 4 (HCO 2 ) 6 ] secondary building units (SBUs) and Ir[bpy(ppy) 2 ] + ‐ or [Ru(bpy) 3 ] 2+ ‐derived tricarboxylate ligands (Hf‐BPY‐Ir or Hf‐BPY‐Ru; bpy=2,2′‐bipyridine, ppy=2‐phenylpyridine) and their applications in X‐ray‐induced photodynamic therapy (X‐PDT) of colon cancer. Heavy Hf atoms in the SBUs efficiently absorb X‐rays and transfer energy to Ir[bpy(ppy) 2 ] + or [Ru(bpy) 3 ] 2+ moieties to induce PDT by generating reactive oxygen species (ROS). The ability of X‐rays to penetrate deeply into tissue and efficient ROS diffusion through ultrathin 2D MOLs (ca. 1.2 nm) enable highly effective X‐PDT to afford superb anticancer efficacy.