Methylenecyclopropane Annulation by Manganese(I)‐Catalyzed Stereoselective C−H/C−C Activation | Zendy

Liang YuFeng | Zendy; Müller Valentin | Zendy; Liu Weiping | Zendy; Münch Annika | Zendy; Stalke Dietmar | Zendy; Ackermann Lutz | Zendy

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Methylenecyclopropane Annulation by Manganese(I)‐Catalyzed Stereoselective C−H/C−C Activation

Author(s) -

Liang YuFeng,

Müller Valentin,

Liu Weiping,

Münch Annika,

Stalke Dietmar,

Ackermann Lutz

Publication year - 2017

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201704767

Subject(s) - annulation , catalysis , chemistry , manganese , rhodium , stereoselectivity , palladium , ruthenium , methylenecyclopropane , cobalt , combinatorial chemistry , metal , medicinal chemistry , stereochemistry , organic chemistry

C−H/C−C functionalizations with methylenecyclopropanes (MCPs) were accomplished with a versatile base‐metal catalyst. A robust manganese(I) complex enabled the expedient annulation of MCPs by synthetically meaningful ketimines to deliver, upon one‐pot hydroarylation, densely substituted polycylic anilines in a step‐economical fashion. Mechanistic studies provided strong support for a facile organometallic C−H manganation, while typical cobalt, ruthenium, rhodium, and palladium catalysts were found completely ineffective.

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