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Manganese‐Catalyzed C−H Functionalizations: Hydroarylations and Alkenylations Involving an Unexpected Heteroaryl Shift
Author(s) -
Wang Chengming,
Wang Ai,
Rueping Magnus
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201704682
Subject(s) - manganese , catalysis , stereoselectivity , chemistry , aryl , surface modification , cascade , bond cleavage , combinatorial chemistry , cleavage (geology) , medicinal chemistry , stereochemistry , organic chemistry , materials science , alkyl , chromatography , fracture (geology) , composite material
A manganese‐catalyzed regio‐ and stereoselective hydroarylation of allenes is reported. The C−H functionalization method provides access to various alkenylated indoles in excellent yields. Moreover, a hydroarylation/cyclization cascade involving an unexpected C−N bond cleavage and aryl shift has been developed, which provides a new synthetic approach to substituted pyrroloindolones.