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Mild Hydrogenation of Amides to Amines over a Platinum‐Vanadium Bimetallic Catalyst
Author(s) -
Mitsudome Takato,
Miyagawa Kazuya,
Maeno Zen,
Mizugaki Tomoo,
Jitsukawa Koichiro,
Yamasaki Jun,
Kitagawa Yasutaka,
Kaneda Kiyotomi
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201704199
Subject(s) - bimetallic strip , catalysis , amide , vanadium , platinum , chemistry , organic chemistry
Hydrogenation of amides to amines is an important reaction, but the need for high temperatures and H 2 pressures is a problem. Catalysts that are effective under mild reaction conditions, that is, lower than 30 bar H 2 and 70 °C, have not yet been reported. Here, the mild hydrogenation of amides was achieved for the first time by using a Pt‐V bimetallic catalyst. Amide hydrogenation, at either 1 bar H 2 at 70 °C or 5 bar H 2 at room temperature was achieved using the bimetallic catalyst. The mild reaction conditions enable highly selective hydrogenation of various amides to the corresponding amines, while inhibiting arene hydrogenation. Catalyst characterization showed that the origin of the catalytic activity for the bimetallic catalyst is the oxophilic V‐decorated Pt nanoparticles, which are 2 nm in diameter.