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Stopping Aerobic Oxidation in Its Tracks: Chemoselective Synthesis of Benzaldehydes from Methylarenes
Author(s) -
Lumb JeanPhilip
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201704160
Subject(s) - aldehyde , catalysis , hydrogen bond , chemistry , carboxylic acid , partial oxidation , combinatorial chemistry , photochemistry , organic chemistry , molecule
A practical and elegant solution to the long‐standing challenge of methylarene partial oxidation has recently been provided by Pappo and co‐workers who devised a catalytic aerobic route to benzaldehydes. The solution hinges on the unique hydrogen‐bonding capacity of hexafluoroisopropanol, which prevents overoxidation of the aldehyde to the carboxylic acid.