Premium
γ‐Functionalizations of Amines through Visible‐Light‐Mediated, Redox‐Neutral C−C Bond Cleavage
Author(s) -
Shu Wei,
Genoux Alexandre,
Li Zhaodong,
Nevado Cristina
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201704068
Subject(s) - cleavage (geology) , chemistry , surface modification , redox , radical , halide , alkyl , bond cleavage , photochemistry , visible spectrum , context (archaeology) , stereochemistry , organic chemistry , catalysis , materials science , paleontology , optoelectronics , fracture (geology) , composite material , biology
Cleavage of unstrained C−C bonds under mild, redox‐neutral conditions represents a challenging endeavor which is accomplished here in the context of a flexible, visible‐light‐mediated, γ‐functionalization of amines. In situ generated C‐centered radicals are harvested in the presence of Michael acceptors, thiols and alkyl halides to efficiently form new C(sp 3 )−C(sp 3 ), C(sp 3 )−H and C(sp 3 )−Br bonds, respectively.