γ‐Functionalizations of Amines through Visible‐Light‐Mediated, Redox‐Neutral C−C Bond Cleavage | Zendy

Shu Wei | Zendy; Genoux Alexandre | Zendy; Li Zhaodong | Zendy; Nevado Cristina | Zendy

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γ‐Functionalizations of Amines through Visible‐Light‐Mediated, Redox‐Neutral C−C Bond Cleavage

Author(s) -

Shu Wei,

Genoux Alexandre,

Li Zhaodong,

Nevado Cristina

Publication year - 2017

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201704068

Subject(s) - cleavage (geology) , chemistry , surface modification , redox , radical , halide , alkyl , bond cleavage , photochemistry , visible spectrum , context (archaeology) , stereochemistry , organic chemistry , catalysis , materials science , paleontology , optoelectronics , fracture (geology) , composite material , biology

Cleavage of unstrained C−C bonds under mild, redox‐neutral conditions represents a challenging endeavor which is accomplished here in the context of a flexible, visible‐light‐mediated, γ‐functionalization of amines. In situ generated C‐centered radicals are harvested in the presence of Michael acceptors, thiols and alkyl halides to efficiently form new C(sp 3 )−C(sp 3 ), C(sp 3 )−H and C(sp 3 )−Br bonds, respectively.

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