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Poly(oligo(ethylene glycol) vinyl acetate)s: A Versatile Class of Thermoresponsive and Biocompatible Polymers
Author(s) -
Hedir Guillaume G.,
Arno Maria C.,
Langlais Marvin,
Husband Jonathan T.,
O'Reilly Rachel K.,
Dove Andrew P.
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201703763
Subject(s) - polymer , ethylene glycol , raft , vinyl acetate , polymer chemistry , polymerization , materials science , chemical engineering , thermoresponsive polymers in chromatography , glass transition , cloud point , chemistry , organic chemistry , phase (matter) , copolymer , composite material , extraction (chemistry) , reversed phase chromatography , engineering
Polymers with a thermally triggered phase transition are important in the design of materials for biological applications, where their behavior can be used to trigger release or (dis)assembly events. Despite their advantages, a system with tunable thermal response, end‐group reactive sites, low toxicity, and controlled main‐chain degradability has not been realized, yet this would be a significant advance. The versatile new poly(oligo(ethylene glycol) vinyl acetate)s are presented with excellent control over their molecular properties obtained through RAFT/MADIX polymerization. Furthermore, we demonstrate structure‐controlled thermal transitions, conjugation to human lysozyme through the retained end‐group, and moreover show that this class of polymers can uniquely be copolymerized with 2‐methylene‐1,3‐dioxepane (MDO) to generate polymers in which the degradability and cloud point can be independently tuned to create materials that display the same cloud point but degrade differently.