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Comment on “A Liposomal System Capable of Generating CO 2 Bubbles to Induce Transient Cavitation, Lysosomal Rupturing and Cell Necrosis”
Author(s) -
Tiefenboeck Peter,
Kim Jong Ah,
Trunk Ferdinand,
Leroux JeanChristophe
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201703740
Subject(s) - cavitation , liposome , transient (computer programming) , payload (computing) , materials science , ammonium bicarbonate , chemistry , nanotechnology , biophysics , mechanics , physics , computer science , biology , raw material , computer network , organic chemistry , network packet , operating system
In 2012 Sung et al. reported temperature‐sensitive liposomes encapsulating ammonium bicarbonate (ABC), supposedly releasing their payload above 42 °C owing to ABC decomposition, subsequent CO 2 bubbles generation, and transient cavitation. In attempts to reproduce the system, insurmountable difficulties have been encountered. New results presented herein cast doubts on the thermoresponsiveness of these liposomes.