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Hydroxamic Acids as Chemoselective ( ortho ‐Amino)arylation Reagents via Sigmatropic Rearrangement
Author(s) -
Shaaban Saad,
Tona Veronica,
Peng Bo,
Maulide Nuno
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201703667
Subject(s) - sigmatropic reaction , chemistry , hydroxamic acid , reagent , aniline , combinatorial chemistry , amino acid , chemoselectivity , organic chemistry , stereochemistry , catalysis , biochemistry
The use of readily available hydroxamic acids as reagents for the chemoselective (ortho‐amino)arylation of amides is described. This reaction proceeds under metal‐free, mild conditions, displays a very broad scope, and constitutes a direct approach for the metal‐free attachment of aniline residues to carbonyl derivatives.
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