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Rhodium(I)‐Catalyzed Tertiary Phosphine Directed C−H Arylation: Rapid Construction of Ligand Libraries
Author(s) -
Qiu Xiaodong,
Wang Minyan,
Zhao Yue,
Shi Zhuangzhi
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201703354
Subject(s) - rhodium , phosphine , ligand (biochemistry) , steric effects , chemistry , aryl , catalysis , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry , receptor , biochemistry , alkyl
Modification of commercially available monophosphine ligands with either aryl bromides or chlorides by rhodium(I)‐catalyzed, tertiary phosphine directed C−H activation is described. A series of ligand libraries containing mono‐ and diaryl‐substituted groups, having different steric and electronic properties, were obtained in high yields. Based on the outstanding properties of their parent scaffolds, the modified ligands have been found to be powerful in organic reactions.