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Catalytic Desymmetrization by C−H Functionalization as a Solution to the Chiral Methyl Problem
Author(s) -
Nagib David A.
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201703311
Subject(s) - desymmetrization , surface modification , catalysis , chemistry , combinatorial chemistry , enantioselective synthesis , organic chemistry
Breaking the mirror (plane) : A palladium‐catalyzed desymmetrization strategy via β C−H activation provides an alternate approach for solving the age‐old challenge of introducing an α‐methyl stereocenter to a molecule.