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Plasmonic‐Based Electrochemical Impedance Imaging of Electrical Activities in Single Cells
Author(s) -
Liu XianWei,
Yang Yunze,
Wang Wei,
Wang Shaopeng,
Gao Ming,
Wu Jie,
Tao gjian
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201703033
Subject(s) - plasmon , electrical impedance , electrical impedance tomography , materials science , optoelectronics , electrochemistry , dielectric spectroscopy , nanotechnology , chemistry , electrode , electrical engineering , engineering
Studying electrical activities in cells, such as action potential and its propagation in neurons, requires a sensitive and non‐invasive analytical tool that can image local electrical signals with high spatial and temporal resolutions. Here we report a plasmonic‐based electrochemical impedance imaging technique to study transient electrical activities in single cells. The technique is based on the conversion of the electrical signal into a plasmonic signal, which is imaged optically without labels. We demonstrate imaging of the fast initiation and propagation of action potential within single neurons, and validate the imaging technique with the traditional patch clamp technique. We anticipate that the plasmonic imaging technique will contribute to the study of electrical activities in various cellular processes.