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Phosphoribosyl Pyrophosphate: A Molecular Vestige of the Origin of Life on Minerals
Author(s) -
Akouche Mariame,
Jaber Maguy,
Maurel MarieChristine,
Lambert JeanFrancois,
Georgelin Thomas
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201702633
Subject(s) - pyrophosphate , ribose , chemistry , nucleotide , phosphorylation , biochemistry , adenosine monophosphate , adenosine , abiogenesis , biophysics , stereochemistry , enzyme , biology , genetics , gene
In this contribution, we report the formation under prebiotic conditions of phosphoribosyl pyrophosphate (PRPP) as a molecular precursor in the one‐pot synthesis of a canonical nucleotide, namely adenosine monophosphate (AMP) from its building blocks (KH 2 PO 4 or P i , adenine, and d ‐ribose), on a fumed silica surface. The on‐the‐rocks approach[1][L. E. Orgel, 1998] has been successfully applied to the simultaneous phosphorylation and glycosylation of ribose. The one‐pot formation mechanism of AMP involves a two‐step pathway via an activated intermediate, namely PRPP, obtained by multiple ribose phosphorylations upon mild thermal activation.