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Temperature‐Driven Planar Chirality Switching of a Pillar[5]arene‐Based Molecular Universal Joint
Author(s) -
Yao Jiabin,
Wu Wanhua,
Liang Wenting,
Feng Yujun,
Zhou Dayang,
Chruma Jason J.,
Fukuhara Gaku,
Mori Tadashi,
Inoue Yoshihisa,
Yang Cheng
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201702542
Subject(s) - enantiopure drug , chirality (physics) , crystallography , ring (chemistry) , chemistry , planar , molecule , circular dichroism , ring flip , spectroscopy , chemical physics , materials science , enantioselective synthesis , physics , chiral symmetry , organic chemistry , computer graphics (images) , quantum mechanics , quark , computer science , nambu–jona lasinio model , catalysis
The study of an enantiopure bicyclic pillar[5]arene‐based molecular universal joint (MUJ) by single‐crystal X‐ray diffraction allowed for the first time the unequivocal assignment of the absolute configuration of a planar chiral pillar[5]arene by circular dichroism spectroscopy. Crucially, the absolute configuration of the MUJ was switched reversibly by temperature, with an accompanying sign inversion of the anisotropy factor that varied by as much as 0.03, which is the largest value ever reported. Mechanistically, the reversible chirality switching of the MUJ is driven by the threading/dethreading motion of the fused ring and hence is dependent on both the size and nature of the ring and the solvent employed, reflecting the critical balance between the self‐complexation of the ring by pillar[5]arene, the solvation to the excluded ring, and the inclusion of solvent molecules in the cavity.