Selective Aerobic Oxidation of Methylarenes to Benzaldehydes Catalyzed by  N ‐Hydroxyphthalimide and Cobalt(II) Acetate in Hexafluoropropan‐2‐ol | Zendy

Gaster Eden | Zendy; Kozuch Sebastian | Zendy; Pappo Doron | Zendy

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Selective Aerobic Oxidation of Methylarenes to Benzaldehydes Catalyzed by N ‐Hydroxyphthalimide and Cobalt(II) Acetate in Hexafluoropropan‐2‐ol

Author(s) -

Gaster Eden,

Kozuch Sebastian,

Pappo Doron

Publication year - 2017

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201702511

Subject(s) - chemoselectivity , autoxidation , benzaldehyde , cobalt , catalysis , chemistry , selectivity , organic chemistry

Efficient and highly selective catalytic conditions for the aerobic autoxidation of methylarenes to benzaldehydes, based on N ‐hydroxyphthalimide (NHPI) and cobalt(II) acetate in 1,1,1,3,3,3‐hexafluoropropan‐2‐ol (HFIP), were developed. The sustainable conditions enable a multigram scale preparation of benzaldehyde derivatives in high efficiency and with excellent chemoselectivity (up to 99 % conversion and 98 % selectivity).

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