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Selective Aerobic Oxidation of Methylarenes to Benzaldehydes Catalyzed by N ‐Hydroxyphthalimide and Cobalt(II) Acetate in Hexafluoropropan‐2‐ol
Author(s) -
Gaster Eden,
Kozuch Sebastian,
Pappo Doron
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201702511
Subject(s) - chemoselectivity , autoxidation , benzaldehyde , cobalt , catalysis , chemistry , selectivity , organic chemistry
Efficient and highly selective catalytic conditions for the aerobic autoxidation of methylarenes to benzaldehydes, based on N ‐hydroxyphthalimide (NHPI) and cobalt(II) acetate in 1,1,1,3,3,3‐hexafluoropropan‐2‐ol (HFIP), were developed. The sustainable conditions enable a multigram scale preparation of benzaldehyde derivatives in high efficiency and with excellent chemoselectivity (up to 99 % conversion and 98 % selectivity).