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A Highly Active Manganese Catalyst for Enantioselective Ketone and Ester Hydrogenation
Author(s) -
Widegren Magnus B.,
Harkness Gavin J.,
Slawin Alexandra M. Z.,
Cordes David B.,
Clarke Matthew L.
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201702406
Subject(s) - catalysis , manganese , noyori asymmetric hydrogenation , enantioselective synthesis , ketone , ligand (biochemistry) , asymmetric hydrogenation , chemistry , chiral ligand , organic chemistry , combinatorial chemistry , biochemistry , receptor
A new hydrogenation catalyst based on a manganese complex of a chiral P,N,N ligand has been found to be especially active for the hydrogenation of esters down to 0.1 mol % catalyst loading, and gives up to 97 % ee in the hydrogenation of pro‐chiral deactivated ketones at 30–50 °C.