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Inside Back Cover: Precisely Regulated and Efficient Locking of Linear Peptides into Stable Multicyclic Topologies through a One‐Pot Reaction (Angew. Chem. Int. Ed. 16/2017)
Author(s) -
Liu Weidong,
Zheng Yiwu,
Kong Xudong,
Heinis Christian,
Zhao Yibing,
Wu Chuanliu
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201702381
Subject(s) - network topology , cover (algebra) , molecule , chemistry , mathematics , topology (electrical circuits) , combinatorics , combinatorial chemistry , stereochemistry , computer science , organic chemistry , engineering , computer network , mechanical engineering
Precisely regulated and efficient locking of linear peptides into multicyclic topologies through a one‐pot reaction (PROP‐locking) is reminiscent of playing with the Kongming lock, a traditional Chinese puzzle game. In their Communication on page 4458 ff., C. Wu et al. report a small phenyl molecule with four isosteric thiolate‐reactive groups of sequentially varied reactivity, and how this molecule was used for PROP‐locking of linear peptides.