B(C 6 F 5 ) 3 ‐Catalyzed Cascade Reduction of Pyridines | Zendy

Liu ZhiYun | Zendy; Wen ZhiHui | Zendy; Wang XiaoChen | Zendy

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B(C 6 F 5 ) 3 ‐Catalyzed Cascade Reduction of Pyridines

Author(s) -

Liu ZhiYun,

Wen ZhiHui,

Wang XiaoChen

Publication year - 2017

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201702304

Subject(s) - hydrosilylation , nitrile , catalysis , cascade , chemistry , realization (probability) , nitro , ketone , reagent , combinatorial chemistry , hydroboration , reduction (mathematics) , medicinal chemistry , organic chemistry , mathematics , geometry , chromatography , statistics , alkyl

B(C 6 F 5 ) 3 has been found to be an effective catalyst for reduction of pyridines and other electron‐deficient N‐heteroarenes with hydrosilanes (or hydroboranes) and amines as the reducing reagents. The success of this development hinges upon the realization of a cascade process of dearomative hydrosilylation (or hydroboration) and transfer hydrogenation. The broad functional‐group tolerance (e.g. ketone, ester, unactivated olefins, nitro, nitrile, heterocycles, etc.) implies high practical utility.

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