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Iridium‐Catalyzed Regio‐ and Enantioselective Hydroarylation of Alkenyl Ethers by Olefin Isomerization
Author(s) -
Ebe Yusuke,
Onoda Mitsuki,
Nishimura Takahiro,
Yorimitsu Hideki
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201702286
Subject(s) - enantioselective synthesis , isomerization , iridium , chemistry , allylic rearrangement , alkoxy group , olefin fiber , aryl , catalysis , medicinal chemistry , ether , regioselectivity , organic chemistry , alkyl
Abstract Iridium‐catalyzed hydroarylation of alkenyl ethers, such as allylic and homoallylic ethers, by C−H bond activation gave high yields of the corresponding addition products, where the aryl groups were selectively installed at the α‐carbon atom to the alkoxy group. The reaction involves an isomerization of the alkenyl ethers into the corresponding 1‐alkenyl ethers, which then undergo the regio‐ and enantioselective hydroarylation.