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Unleashing the Potential of 17 O NMR Spectroscopy Using Mechanochemistry
Author(s) -
Métro ThomasXavier,
Gervais Christel,
Martinez Anthony,
Bonhomme Christian,
Laurencin Danielle
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201702251
Subject(s) - mechanosynthesis , mechanochemistry , nuclear magnetic resonance spectroscopy , reactivity (psychology) , spectroscopy , chemistry , characterization (materials science) , obstacle , molecule , solid state nuclear magnetic resonance , nanotechnology , materials science , organic chemistry , physics , nuclear magnetic resonance , medicine , pathology , quantum mechanics , political science , law , composite material , ball mill , alternative medicine
17 O NMR spectroscopy has been the subject of vivid interest in recent years, because there is increasing evidence that it can provide unique insight into the structure and reactivity of many molecules and materials. However, due to the very poor natural abundance of oxygen‐17, 17 O labeling is generally a prerequisite. This is a real obstacle for most research groups, because of the high costs and/or strong experimental constraints of the most frequently used 17 O‐labeling schemes. Here, we show for the first time that mechanosynthesis offers unique opportunities for enriching in 17 O a variety of organic and inorganic precursors of synthetic interest. The protocols are fast, user‐friendly, and low‐cost, which makes them highly attractive for a broad research community, and their suitability for 17 O solid‐state NMR applications is demonstrated.