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Air‐Stable Manganese(I)‐Catalyzed C−H Activation for Decarboxylative C−H/C−O Cleavages in Water
Author(s) -
Wang Hui,
Lorion Mélanie M.,
Ackermann Lutz
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201702193
Subject(s) - manganese , catalysis , chemistry , metalation , substrate (aquarium) , aryl , selectivity , medicinal chemistry , surface modification , stereochemistry , combinatorial chemistry , organic chemistry , oceanography , alkyl , geology
The decarboxylative C−H/C−O functionalization was accomplished by air‐ and water‐tolerant manganese(I) catalysis. The versatile C−H allylation occurred by facile organometallic C−H metalation on indoles, arenes, amino acids and synthetically meaningful aryl ketimines with ample substrate scope and high levels of chemo‐, site‐ and regio‐selectivity.