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Inside Cover: Positional Enrichment by Proton Analysis (PEPA): A One‐Dimensional 1 H‐NMR Approach for 13 C Stable Isotope Tracer Studies in Metabolomics (Angew. Chem. Int. Ed. 13/2017)
Author(s) -
Vinaixa Maria,
Rodríguez Miguel A.,
Aivio Suvi,
Capellades Jordi,
Gómez Josep,
Canyellas Nicolau,
Stracker Travis H.,
Yanes Oscar
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201702039
Subject(s) - chemistry , metabolomics , nuclear magnetic resonance spectroscopy , isotope , stable isotope ratio , stereochemistry , chromatography , physics , quantum mechanics
Elucidating the flow of chemical moieties through the complex set of metabolic reactions in the cell is essential for understanding the regulation of cell metabolism in health and disease. In their Communication on page 3531 ff., M. Vinaixa, O. Yanes et al. report a novel technique for extending high‐throughput 1 H‐1D‐NMR metabolic profiling to stable isotope tracing. This approach expands the range of isotopically enriched metabolites detected in cellular extracts beyond 13 C‐NMR and 2D‐NMR experiments, thus accelerating the implementation of NMR spectroscopy in cell metabolism studies.