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Ligand‐Promoted meta ‐C−H Functionalization of Benzylamines
Author(s) -
Wang Peng,
Farmer Marcus E.,
Yu JinQuan
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201701803
Subject(s) - chemistry , surface modification , amination , ligand (biochemistry) , substrate (aquarium) , combinatorial chemistry , mediator , stereochemistry , organic chemistry , catalysis , receptor , biochemistry , medicine , oceanography , geology
Meta‐C−H functionalization of benzylamines has been developed using a Pd II /transient mediator strategy. Using 2‐pyridone ligands and 2‐carbomethoxynorbornene (NBE‐CO 2 Me) as the mediator, arylation, amination, and chlorination of benzylamines are realized. This protocol features a broad substrate scope and is compatible with heterocylic coupling partners. Moreover, the loading of the Pd can be lowered to 2.5 mol % by using the optimal ligand.