Ligand‐Promoted  meta ‐C−H Functionalization of Benzylamines | Zendy

Wang Peng | Zendy; Farmer Marcus E. | Zendy; Yu JinQuan | Zendy

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Ligand‐Promoted meta ‐C−H Functionalization of Benzylamines

Author(s) -

Wang Peng,

Farmer Marcus E.,

Yu JinQuan

Publication year - 2017

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201701803

Subject(s) - chemistry , surface modification , amination , ligand (biochemistry) , substrate (aquarium) , combinatorial chemistry , mediator , stereochemistry , organic chemistry , catalysis , receptor , biochemistry , medicine , oceanography , geology

Meta‐C−H functionalization of benzylamines has been developed using a Pd II /transient mediator strategy. Using 2‐pyridone ligands and 2‐carbomethoxynorbornene (NBE‐CO 2 Me) as the mediator, arylation, amination, and chlorination of benzylamines are realized. This protocol features a broad substrate scope and is compatible with heterocylic coupling partners. Moreover, the loading of the Pd can be lowered to 2.5 mol % by using the optimal ligand.

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