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Multi‐shelled Dendritic Mesoporous Organosilica Hollow Spheres: Roles of Composition and Architecture in Cancer Immunotherapy
Author(s) -
Yang Yannan,
Lu Yao,
Abbaraju Prasanna Lakshmi,
Zhang Jun,
Zhang Min,
Xiang Guangya,
Yu Chengzhong
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201701550
Subject(s) - adjuvant , immunotherapy , cancer immunotherapy , rational design , mesoporous material , composition (language) , materials science , immune system , cancer , mesoporous silica , nanotechnology , medicine , chemistry , immunology , catalysis , organic chemistry , linguistics , philosophy
Developing potent adjuvants for the stimulation of robust immune response is central for effective cancer immunotherapy. Double‐shelled dendritic mesoporous organosilica hollow spheres are an excellent adjuvant and provide superior immunity in cancer immunotherapy, and better than their counterparts either with a pure silica composition or a single‐walled architecture. This study provides new insights in the rational design of effective nanostructured adjuvants for vaccine developments.