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Domino N ‐/ C ‐Arylation via In Situ Generation of a Directing Group: Atom‐Efficient Arylation Using Diaryliodonium Salts
Author(s) -
Teskey Christopher J.,
Sohel Shariar M. A.,
Bunting Danielle L.,
Modha Sachin G.,
Greaney Michael F.
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201701523
Subject(s) - domino , aryl , in situ , ruthenium , chemistry , atom (system on chip) , catalysis , group (periodic table) , functional group , combinatorial chemistry , cascade reaction , atom economy , medicinal chemistry , organic chemistry , computer science , embedded system , alkyl , polymer
Both aryl components of diaryliodonium salts can be used in a domino one‐pot reaction via in situ generation of a directing group. A number of heterocycles undergo N‐arylation which is followed by ruthenium‐catalyzed C‐arylation. Notably the reaction extends well to unsymmetrical diaryliodonium salts with a number of highly selective examples shown.