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Inside Cover: Enantioselective Aza‐Ene‐type Reactions of Enamides with Gold Carbenes Generated from α‐Diazoesters (Angew. Chem. Int. Ed. 12/2017)
Author(s) -
Zhao Feng,
Li Nan,
Zhang Tao,
Han ZhiYong,
Luo ShiWei,
Gong LiuZhu
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201701298
Subject(s) - enantioselective synthesis , chemistry , ene reaction , int , combinatorial chemistry , decomposition , cover (algebra) , catalysis , stereochemistry , medicinal chemistry , organic chemistry , mechanical engineering , computer science , engineering , operating system
Carbophilic gold carbenes generated by the decomposition of α‐diazoesters are highly reactive towards enamides, undergoing an unprecedented aza‐ene‐type reaction. In their Communication on page 3247 ff., S.‐W. Luo, L.‐Z. Gong, and co‐workers show that the presence of 0.1 mol % of a chiral Brønsted acid is sufficient to obtain synthetically significant γ‐keto esters in high yields and with excellent enantioselectivities.