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Annulative π‐Extension (APEX): Rapid Access to Fused Arenes, Heteroarenes, and Nanographenes
Author(s) -
Ito Hideto,
Ozaki Kyohei,
Itami Kenichiro
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201701058
Subject(s) - apex (geometry) , chemistry , agrochemical , nanotechnology , combinatorial chemistry , extension (predicate logic) , materials science , computer science , mathematics , ecology , geometry , programming language , biology , agriculture
The annulative π‐extension (APEX) reaction has the potential to have a tremendous impact on the fields of materials science and bioimaging, as well as on the pharmaceutical/agrochemical industries, since it allows access to fused aromatic systems from relatively simple aromatic compounds in a single step. Typically, an APEX reaction facilitates a one‐pot π‐extension without the need to prefunctionalize the aromatic compounds. This advantageous feature is extremely useful for tuning and modifying molecular properties in the last step of a synthesis. In this Review, the progress and applications of APEX reactions of unfunctionalized arenes and heteroarenes are described.