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One‐Pot Multicomponent Synthesis of β‐Amino Amides
Author(s) -
Huang Bo,
Zeng Linwei,
Shen Yangyong,
Cui Sunliang
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201700840
Subject(s) - combinatorial chemistry , amino acid , chemistry , scalability , reaction conditions , isotopic labeling , molecule , organic chemistry , computer science , catalysis , biochemistry , database
Multicomponent reactions are excellent tools for rapid generation of small molecules with broad chemical diversity and molecular complexity. Herein, a novel one‐pot multicomponent synthesis of β‐amino amides from aldehydes, anilines, carboxylic acids and ynamides has been successfully developed. This process is practical and efficient to unravel synthetic utility and scalability. Moreover, an isotope labeling reaction was conducted to elucidate a plausible reaction mechanism.