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Yttrium‐Catalyzed Intramolecular Hydroalkoxylation/Claisen Rearrangement Sequence: Efficient Synthesis of Medium‐Sized Lactams
Author(s) -
Zhou Bo,
Li Long,
Zhu XinQi,
Yan JuanZhu,
Guo YiLin,
Ye LongWu
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201700596
Subject(s) - intramolecular force , yttrium , claisen rearrangement , sequence (biology) , catalysis , combinatorial chemistry , chemistry , cascade , stereochemistry , organic chemistry , biochemistry , oxide , chromatography
An efficient yttrium‐catalyzed intramolecular hydroalkoxylation/Claisen rearrangement sequence has been achieved, thus enabling facile access to a diverse array of valuable medium‐sized lactams. Furthermore, a mechanistic rationale for this novel cascade reaction is well supported by a variety of control experiments.