Visible‐Light‐Promoted Asymmetric Cross‐Dehydrogenative Coupling of Tertiary Amines to Ketones by Synergistic Multiple Catalysis | Zendy

Yang Qi | Zendy; Zhang Long | Zendy; Ye Chen | Zendy; Luo Sanzhong | Zendy; Wu LiZhu | Zendy; Tung ChenHo | Zendy

Premium

Visible‐Light‐Promoted Asymmetric Cross‐Dehydrogenative Coupling of Tertiary Amines to Ketones by Synergistic Multiple Catalysis

Author(s) -

Yang Qi,

Zhang Long,

Ye Chen,

Luo Sanzhong,

Wu LiZhu,

Tung ChenHo

Publication year - 2017

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201700572

Subject(s) - catalysis , iminium , enamine , chemistry , tetrahydroisoquinoline , combinatorial chemistry , amine gas treating , photochemistry , photocatalysis , synergistic catalysis , organic chemistry

Reported herein is an unprecedented photocatalytic asymmetric cross‐dehydrogenative coupling reaction between tertiary amines and simple ketones, and it proceeds by synergistic multiple catalysis with substoichiometric amounts of a hydrogen acceptor. This process is enabled by a simple chiral primary amine catalyst through the coupling of a catalytic enamine intermediate and an iminium cation intermediate in situ generated from tetrahydroisoquinoline derivatives by coupled Ru/Co catalysis.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research