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Merging Distal Alkynyl Migration and Photoredox Catalysis for Radical Trifluoromethylative Alkynylation of Unactivated Olefins
Author(s) -
Xu Yan,
Wu Zhen,
Jiang Jingxing,
Ke Zhuofeng,
Zhu Chen
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201700413
Subject(s) - alkynylation , intramolecular force , photoredox catalysis , chemistry , catalysis , radical , redox , photochemistry , inert , combinatorial chemistry , reaction conditions , photocatalysis , organic chemistry
Disclosed herein is a novel, redox‐neutral protocol for the visible‐light‐induced radical alkynylation of unactivated olefins. The intramolecular migration of an alkynyl group, by cleaving an inert C−C σ bond, is realized for the first time. A wide range of synthetically useful trifluoroethylated linear alkynes are readily obtained under mild reaction conditions.