Merging Distal Alkynyl Migration and Photoredox Catalysis for Radical Trifluoromethylative Alkynylation of Unactivated Olefins | Zendy

Xu Yan | Zendy; Wu Zhen | Zendy; Jiang Jingxing | Zendy; Ke Zhuofeng | Zendy; Zhu Chen | Zendy

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Merging Distal Alkynyl Migration and Photoredox Catalysis for Radical Trifluoromethylative Alkynylation of Unactivated Olefins

Author(s) -

Xu Yan,

Wu Zhen,

Jiang Jingxing,

Ke Zhuofeng,

Zhu Chen

Publication year - 2017

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201700413

Subject(s) - alkynylation , intramolecular force , photoredox catalysis , chemistry , catalysis , radical , redox , photochemistry , inert , combinatorial chemistry , reaction conditions , photocatalysis , organic chemistry

Disclosed herein is a novel, redox‐neutral protocol for the visible‐light‐induced radical alkynylation of unactivated olefins. The intramolecular migration of an alkynyl group, by cleaving an inert C−C σ bond, is realized for the first time. A wide range of synthetically useful trifluoroethylated linear alkynes are readily obtained under mild reaction conditions.

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