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Merging N‐Heterocyclic Carbene Catalysis and Single Electron Transfer: A New Strategy for Asymmetric Transformations
Author(s) -
Zhao Kun,
Enders Dieter
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201700370
Subject(s) - carbene , catalysis , electron transfer , chemistry , combinatorial chemistry , photochemistry , organic chemistry
Radical chemistry meets NHCs : NHC catalysis and single electron oxidants have been merged in several transformations, allowing the synthesis of useful β‐hydroxy esters, cyclopentanones, and spirocyclic γ‐lactones in a highly stereoselective manner. The key step is the oxidation of the NHC homoenolate equivalent to a radical species via a single‐electron transfer process (see scheme).