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DNA Films Containing the Artificial Nucleobase Imidazole Mediate Charge Transfer in a Silver(I)‐Responsive Way
Author(s) -
Léon J. Christian,
She Zhe,
Kamal Ajar,
Shamsi Mohtashim Hassan,
Müller Jens,
Kraatz HeinzBernhard
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201700248
Subject(s) - imidazole , x ray photoelectron spectroscopy , nucleobase , electron transfer , dna , circular dichroism , dielectric spectroscopy , metal , materials science , electrochemistry , crystallography , chemistry , photochemistry , stereochemistry , organic chemistry , electrode , chemical engineering , biochemistry , engineering
The first sequence‐dependent study of DNA films containing metal‐mediated base pairs was performed to investigate the charge transfer resistance (R CT ) of metal‐modified DNA. The imidazole (Im) deoxyribonucleoside was chosen as a highly Ag I ‐specific ligandoside for the formation of Im–Ag I –Im complexes within the duplexes. This new class of site‐specifically metal‐modified DNA films was characterized by UV, circular dichroism (CD), and X‐ray photoelectron spectroscopy (XPS). The electrochemical properties of these systems were investigated by means of electron impedance spectroscopy and scanning electrochemical microscopy. Taken together, these experiments indicated that the incorporation of Ag I ions into the DNA films leads to reduced electron transfer through the DNA films. A simple device was proposed that can be switched reversibly between two distinct states with different charge transfer resistance.