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Next‐Generation Polymer Shells for Inorganic Nanoparticles are Highly Compact, Ultra‐Dense, and Long‐Lasting Cyclic Brushes
Author(s) -
Morgese Giulia,
Shirmardi Shaghasemi Behzad,
Causin Valerio,
ZenobiWong Marcy,
Ramakrishna Shivaprakash N.,
Reimhult Erik,
Benetti Edmondo M.
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201700196
Subject(s) - colloid , nanoparticle , polymer , superparamagnetism , chemical engineering , materials science , nanotechnology , bovine serum albumin , chemistry , polymer chemistry , organic chemistry , chromatography , physics , magnetization , engineering , quantum mechanics , magnetic field
Cyclic poly‐2‐ethyl‐2‐oxazoline (PEOXA) ligands for superparamagnetic Fe 3 O 4 nanoparticles (NPs) generate ultra‐dense and highly compact shells, providing enhanced colloidal stability and bio‐inertness in physiological media. When linear brush shells fail in providing colloidal stabilization to NPs, the cyclic ones assure long lasting dispersions. While the thermally induced dehydration of linear PEOXA shells cause irreversible aggregation of the NPs, the collapse and subsequent rehydration of similarly grafted cyclic brushes allow the full recovery of individually dispersed NPs. Although linear ligands are densely grafted onto Fe 3 O 4 cores, a small plasma protein such as bovine serum albumin (BSA) still physisorbs within their shells. In contrast, the impenetrable entropic shield provided by cyclic brushes efficiently prevents nonspecific interaction with proteins.