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Nanomechanical Infrared Spectroscopy with Vibrating Filters for Pharmaceutical Analysis
Author(s) -
Kurek Maksymilian,
Carnoy Matthias,
Larsen Peter E.,
Nielsen Line H.,
Hansen Ole,
Rades Thomas,
Schmid Silvan,
Boisen Anja
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201700052
Subject(s) - infrared spectroscopy , spectroscopy , infrared , materials science , analyte , photothermal therapy , sample preparation , analytical chemistry (journal) , photothermal spectroscopy , sample (material) , nanotechnology , chemistry , optics , chromatography , organic chemistry , physics , quantum mechanics
Standard infrared spectroscopy techniques are well‐developed and widely used. However, they typically require milligrams of sample and can involve time‐consuming sample preparation. A promising alternative is represented by nanomechanical infrared spectroscopy (NAM‐IR) based on the photothermal response of a nanomechanical resonator, which enables the chemical analysis of picograms of analyte directly from a liquid solution in only a few minutes. Herein, we present NAM‐IR using perforated membranes (filters). The method was tested with the pharmaceutical compound indomethacin to successfully perform a chemical and morphological analysis on roughly 100 pg of sample. With an absolute estimated sensitivity of 109±15 fg, the presented method is suitable for ultrasensitive vibrational spectroscopy.
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