Premium
Electrocatalytic Oxidant‐Free Dehydrogenative C−H/S−H Cross‐Coupling
Author(s) -
Wang Pan,
Tang Shan,
Huang Pengfei,
Lei Aiwen
Publication year - 2017
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201700012
Subject(s) - electrolysis , yield (engineering) , chemistry , aryl , catalysis , combinatorial chemistry , environmentally friendly , radical , medicinal chemistry , photochemistry , organic chemistry , materials science , alkyl , electrode , biology , electrolyte , metallurgy , ecology
An environmentally friendly electrocatalytic protocol has been developed for dehydrogenative C−H/S−H cross‐coupling. This method enabled C−S bond formation under catalyst‐ and oxidant‐free conditions. Under undivided electrolysis conditions, various aryl/heteroaryl thiols and electron‐rich arenes afforded the C−S bond‐formation products in 24–99 % yield. A preliminary mechanistic study indicated that the generation of aryl radical cation intermediates is key to the success of this transformation.