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Frontispiece: Glyceride‐Mimetic Prodrugs Incorporating Self‐Immolative Spacers Promote Lymphatic Transport, Avoid First‐Pass Metabolism, and Enhance Oral Bioavailability
Author(s) -
Hu Luojuan,
Quach Tim,
Han Sifei,
Lim Shea F.,
Yadav Preeti,
Senyschyn Danielle,
Trevaskis Natalie L.,
Simpson Jamie S.,
Porter Christopher J. H.
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201684461
Subject(s) - prodrug , bioavailability , glyceride , chemistry , drug , metabolism , pharmacology , drug metabolism , first pass effect , biochemistry , medicine , fatty acid
Prodrugs In their Communication on page 13700 ff., J. S. Simpson, C. H. J. Porter et al. report how the oral bioavailability of testosterone is significantly enhanced by generating glyceride‐based prodrugs that promote drug release and direct the drugs to the lymphatic system.