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Frontispiece: Activation of Platinum(IV) Prodrugs By Motexafin Gadolinium as a Redox Mediator
Author(s) -
Thiabaud Gregory,
McCall Rebecca,
He Guangan,
Arambula Jonathan F.,
Siddik Zahid H.,
Sessler Jonathan L.
Publication year - 2016
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201684161
Subject(s) - prodrug , gadolinium , redox , chemistry , in vitro , mediator , platinum , vitamin c , combinatorial chemistry , medicine , catalysis , biochemistry , inorganic chemistry , organic chemistry
Antitumor Agents In their Communication on page 12626 ff., Z. H. Siddik, J. L. Sessler, and co‐workers show that in the presence of vitamin C, gadolinium texaphyrin accelerates the reduction of Pt IV prodrugs in vitro to give the active Pt II species.